Job Description

My client is an exciting and rapidly growing Biotech startup at the forefront of innovation located in the Boston Area who are currently undergoing an expansion due to securing a significant series A funding round. They are seeking a dynamic and experienced individual to join their team as the to help develop their RNA Biochemistry activities at a Senior Scientist level.

Responsibilities:

You will apply your expertise in Biochemistry to establish functional and binding assays for RNA-binding proteins and/or RNAs with small molecules.

You will be the Biochemistry lead on projects and play a key role in drug discovery

You will explore and evaluate new biochemical methods to support drug discovery

You will take a leadership role in the design and scoping of project initiatives

You will drive the development of experimental designs for understanding protein and RNA interactions

You will establish, troubleshoot, and improve biochemical screening assays

You will manage and actively engage in collaborations with CROs. You will work closely with a multidisciplinary team to screen and validate small molecule hits.

You will work in a highly cross-disciplinary team and oversee the activities of junior scientists while conducting your own independent experiments

Qualifications:

You have a PhD with 3+ years of post-doctoral training in Biochemistry or equivalent

You have at least 2+ years of industry experience and have worked in an interdisciplinary environment where you have closely worked with medicinal chemists

You have a strong publication record from PhD and Post-doc that demonstrates your expertise in Biochemistry

Expertise in establishing functional assays with techniques such as TR-FRET, Alpha-LISA, and Fluorescent Polarization

Experience with RNA biochemistry, synthesis, purification, characterization, and structural evaluation with techniques including crystallography, SHAPE-MaP, or NMR is strongly preferred

Experience in protein/protein, protein/RNA, RNA/small molecule or protein/small molecule interactions by DSF, ITC, and/or MST and have applied these to small molecule drug discovery preferred

You have an understanding of protein expression and purification

You can thrive in a fast-paced start-up environment

You have excellent communication and interpersonal skills

Benefits:

Based in the Boston Area

Competitive salary of $140-160,000 pa and extensive benefits package

Progression opportunities – Chance to get on the ground floor with a well-funded and rapidly expanding Biotech

Comprehensive health, dental, and vision insurance

Stock options for eligible employees

If you are looking to take the next step in your career in the Biotech industry and you would like to know more about this role or the other opportunities we currently have on our books, please apply now with your CV to speak with our specialist Scientific Consultant William Ashbrook

Job Tags

Permanent employment,

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